P4 Aldosterone-Induced Vascular Dysfunction by Decreasing Nuclear Factor Erythroid 2–Related Factor 2 Activity and Increasing Reactive Oxygen Species Generation
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چکیده
منابع مشابه
Reactive Oxygen Species and Nuclear Factor Erythroid 2-Related Factor 2 Activation in Diabetic Nephropathy: A Hidden Target
Hyperglycemia, oxidative stress and renin-angiotensin system (RAS) dysfunction have been implicated in diabetic nephropathy (DN) progression, but the underlying molecular mechanisms are far from being fully understood. In addition to the systemic RAS, the existence of a local intrarenal RAS in renal proximal tubular cells has been recognized. Angiotensinogen is the sole precursor of all angiote...
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Oxidative stress is implicated in vascular dysfunction in hypertension. Although mechanisms regulating vascular pro-oxidants are emerging, there is a paucity of information on antioxidant systems, particularly nuclear factor erythroid 2-related factor (Nrf2), a master regulator of antioxidants enzymes. We evaluated the vascular regulatory role of Nrf2 in hypertension and examined molecular mech...
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ژورنال
عنوان ژورنال: Artery Research
سال: 2020
ISSN: 1876-4401
DOI: 10.2991/artres.k.191224.039